foxo1 | foxo1 function

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foxo1*******Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to . See moreAdipogenesisFOXO1 negatively regulates adipogenesis. Presently, the exact mechanism by which this is accomplished . See more

In its un-phosphorylated state, FOXO1 is localized to the nucleus, where it binds to the insulin response sequence located in the promoter for glucose 6-phosphatase and increases its rate . See moreBecause FOXO1 provides a link between transcription and metabolic control by insulin, it is also a potential target for genetic control of type 2 diabetes. In the insulin-resistant . See moreFOXO1 has been shown to interact with:• androgen receptor,• estrogen receptor alpha,• CREB-binding protein, and See moreThere are three processes, namely acetylation, phosphorylation, and ubiquitination that are responsible for regulation of the . See more

• Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.• In Gluconeogenesis, FOXO1 gene . See more• FOXO1A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)This article incorporates text from the United States National Library of Medicine See more Among the genes induced by FOXO1 is TCF7, which has been broadly implicated in memory programming, stemness and antitumor activity in human and . FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to . FOXO1 is now found to directly control the expression of pluripotency regulators in human embryonic stem cells, with a FOXO1 orthologue performing a similar function in mouse embryonic stem cells .

FoxO1 mKO macrophages are skewed toward an M2 phenotype in physiological state. FoxO1 is a diversified transcriptional factor but little is known about its role in macrophage metabolism and . Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body energy metabolism. Glucose homeostasis is achieved by adjusting endogenous glucose production as well .

FOXO1 deficiency impairs B-cell development, due to decreased expression of its critical target genes, that include early B-cell factor (EBF1), IL-7 receptor, recombination activating genes (RAG1 and 2), activation-induced cytidine deaminase (AID), L-selectin, and BLNK. Taken together, FOXO1 is an important node in a dynamic network of . KSHV hijacks FoxO1 to promote cell proliferation and cellular transformation by antagonizing oxidative stress. Li T, et al.J Med Virol, 2023 Mar. PMID 36929740, Free PMC Article PAX-FOXO1 fusion status in children and adolescents with alveolar rhabdomyosarcoma: Impact on clinical, pathological, and survival features. FOXO1 and FOXO3 are the major FOXO paralogues expressed in T cells, and they have distinct (but sometimes overlapping) functions in T cell survival and differentiation. Genetic experiments .

foxo1 foxo1 functionFoxO1 haploinsufficiency reversed the characteristic pancreatic β-cell failure, which is thought to be highly related to type 2 Diabetes. These data suggest that FoxO1 is involved in the regulation of β cell proliferation and functions as a negative regulator of insulin sensitivity . Consistent with the finding that FoxO1 becomes . Figure 1: Endothelial FOXO1 is an essential regulator of vascular growth. a, Staining for FOXO1, VE-cadherin (VECAD) and isolectin-B4 (IB4) in a postnatal day (P)5 mouse retina. The bottom panels . FOXO1 knock down in Cal-27 cells resulted in repression of E-cadherin and B-catenin while there was a surge in the expression of N-cadherin and vimentin both in mRNA and protein levels . Further work on EZH2 abrogated Cal-27 and Tca8113 cells confirmed the role of FOXO1 in EMT. EZH2 knock down downregulated STAT3, a latent . The forkhead box protein O1 (FOXO1) is considered to be a key tumor suppressor due to its involvement in a broad range of cancer-related functions, including cellular differentiation, apoptosis .foxo1 FoxO1 signaling pathway involved in skeletal muscle differentiation. The FoxO1 upstream signals including IGFs, insulin and IRS regulate FoxO1 transcriptional activity through phosphorylating FoxO1 in a PI3K-Akt dependent manner. Phosphorylated FoxO1 will be excluded from nucleus and thus loses its capacity of binding to target .foxo1 function FoxO1 signaling pathway involved in skeletal muscle differentiation. The FoxO1 upstream signals including IGFs, insulin and IRS regulate FoxO1 transcriptional activity through phosphorylating FoxO1 in a PI3K-Akt dependent manner. Phosphorylated FoxO1 will be excluded from nucleus and thus loses its capacity of binding to target . 1. Introduction. The forkhead box O (FoxO) protein family consists of four major members in mammals, namely FoxO1, FoxO3a, FoxO4 and FoxO6. They are distinct in tissue distribution and regulatory function while sharing a common DNA binding domain, which can recognize the cis-element of “TTGTTTAC” motif [].FoxO1, the first .

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foxo1|foxo1 function